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Forschungsschwerpunkte

Forschungsschwerpunkte der Arbeitsgruppe „Experimentelle Pankreatologie“
Leiter: PD Dr. rer. nat. habil. Heike Weber
Mitarbeiter: M. Sc. Juliane Rothe

(gefördert durch BMBF, DFG, FORUN, Pankreasverbund der Medizinischen Fakultät Rostock)

  • Molekulare Mechanismen der Zellschädigung in der Pathogenese der akuten Pankreatitis
  • Untersuchungen zum Einsatz von Isoflavonoiden in der Chemoprävention und Therapie des Pankreaskarzinoms (in vitro)

      Ausgewählte Publikationen der Arbeitsgruppe (2000-2014):

  1. Weber H, Jonas L, Wakileh M, Krüger B. Beneficial effect of the bioflavonoid quercetin on cholecystokinin-induced mitochondrial dysfunction in isolated rat pancreatic acinar cells. Can J Physiol Pharmacol 2014; 92: 215-25.
  2. Weber H, Müller L, Jonas L, Schult C, Sparmann G, Schuff-Werner P. Calpain mediates caspase-dependent apoptosis initiated by hydrogen peroxide in pancreatic acinar AR42J cells. Free Rad Res 2013; 47: 432-447.
  3. Weber H, Hühns S, Lüthen F, Jonas L. Calpain-mediated breakdown of cytoskeletal proteins contributes to cholecystokinin-induced damage of rat pancreatic acini. Int J Exp Pathol 2009; 90: 387-399.
  4. Weber H, Hühns S, Jonas L, Sparmann G, Bastian M, Schuff-Werner P. Hydrogen peroxide-induced activation of defense mechanisms against oxidative stress in rat pancreatic acinar AR42J cells. Free Radical Biol Med Res 2007; 42: 830-841.
  5. Lemke M, Görl N, Berg A, Weber H, Hennighausen G, Merkord J. Influence of selenium treatment on the acute toxicity of dibutyltin dichloride in rats. Pancreatology 2006; 6: 486-496.
  6. Weber H, Hühns S, Lüthen F, Jonas L, Schuff-Werner P. Calpain activation contributes to oxidative stress-induced pancreatic acinar cell injury. Biochem Pharmacol 2005; 70: 1241-1252.
  7. Weber H, Jonas L, Hühns S, Schuff-Werner P. Dysregulation of the calpain-calpastatin system plays a role in the development of cerulein-induced acute pancreatitis in the rat. Am J Physiol Gastrointest Liver Physiol 2004; 286: G932-G941.
  8. Siegmund E, Lüthen F, Kunert J, Weber H. Ethanol modifies the actin cytoskeleton in rat pancreatic acinar cells. Comparison with effects of CCK. Pancreatology 2004; 4: 12-21.
  9. Weber H, Hopp-H-H, Noack T, Wagner ACC, Schuff-Werner P. Expression and regulation of calpain in rat pancreatic acinar cells. Pancreas 2002; 24: 63-74.
  10. Weber H, Wagner ACC, Jonas L, Merkord J, Höfken T, Nizze H, Leitzmann P, Göke; Schuff-Werner P. Heat shock response is associated with protection against acute interstitial pancreatitis in rats. Dig Dis Sci 2000; 45: 2252-2264

      Ausgewählte Abstracts der Arbeitsgruppe:

  1. Weber H, Müller L, Schuff-Werner. Calpain activation contributes to apoptosis in pancreatic AR42J cells induced by oxidative stress. Gastroenterology 2011; 140: S-387; Digestive Disease Week; 2011, Chicago, USA
  2. Weber H, Hühns S, Lüthen F, Jonas L. Calpain-mediated breakdown of cytoskeletal proteins contributes to disassembly of the actin cytoskeleton in rat pancreatic acinar cells during acute pancreatitis. Gastroenterology 2008; 134 (Suppl 1): A429. Digestive Disease Week, May 2008, San Diego, USA
  3. Mehrlaender M, Sparmann G, Jaster R, Weber H, Liebe S, Emmrich J. Tumor cells induce MMP-9 synthesis in rat pancreatic stellate cells- potential role of EMMPRIN. Gastroenterology 2006; 130 (Suppl 2): 677. Digestive Disease Week, May 2006; San Diego, USA
  4. Weber H, Jonas H, Huehns S, Schuff-Werner P. Dysregulation of the calpain-calpastatin system plays a role in the development of cerulein-induced acute pancreatitis in the rat. Gastroenterology 2004; 126 (Suppl 2) M1687. Digestive Disease Week, May 2004, New Orleans, USA
  5. Riackeheer K, Sparmann G, Kleine H-D, Weber H, Liebe S, Emmrich J. Immune-mediated experimental chronic pancreatitis. Gastroenterology 2001; 120 (Issue 5) A720; Digestive Disease Week, May 2001, Atlanta, USA
  6. Weber H, Nebe B, Schuff-Werner P. Oxidant-induced activation of the cytosolic cysteine protease calpain causes morphological alterations of isolated rat pancreatic acinar cells. Gastroenterology 2000; 118 (Issue 4) A430; Digestive Disease Week, May 2000, San Diego, USA
  7. Weber H, Hopp H-H, Noack T, Schuff-Werner P. Identification of the Ca2+-regulated cytosolic cysteine protease calpain in rat pancreatic acinar cells. Gastroenterology 2000; 118 (Issue 4) A171. Digestive Disease Week, May 2000, San Diego, USA
  8. Weber H, Wagner ACC, Merkord J, Jonas L, Nizze H, Schuff-Werner P. Hyperthermia-mediated protection against acute pancreatitis is associated with an activation of the pancreatic antioxidative defense system. Gastroenterology 1998; 114 (No 4; Part 2) G2072; Digestive Disease Week, May 1998; New Orleans, USA
  9. Weber H, Roesner J, Nebe B, Jonas L, Schneider KP, Werner A. Increased cytosolic Ca2+ amplifies oxygen radical-induced alterations of the ultrastructure and the energy metabolism of isolated rat pancreatic acinar cells. Gastroenterology 1997; 112: A-149. Digestive Disease Week; May 1997, Washington, USA